Spiritueller Weg

[mikel015]

[mikel015]

[Gaucho]

Zum Thema 3-HO PCP...so handelt es sich hierbei um ein wundervolles Heil oder auch Hilfsmittel zur Auflösung schwerster Depressionszzustände über einen längeren Zeitraum von vielen Wochen, bei nur einmaliger Einnahme. Wer sich ein wenig damit genauer befasst und über den entsprechenden Smilesstringe bei Swisstargetprediction die genaue biochemische Wirkungsweise über die Neurotransmitter anschaut, der wird feststellen, dass es fast zu schön um wahr zu sein scheint.

Wie auch Ketamin und PCP gehört es zur altbewährten Stoffgruppe der Arylcyclohexylamine, hat aber im Gegensatz zu diesen beiden und anderen Derivaten aus dieser Stoffgruppe ganz besondere Eigenschaften, die es eben einzigartig in seiner Komplexität machen.

Denn neben seiner hohen Potenz (8 mal so stark wie normales PCP) wirkt es auch deutlich länger und deckt neben seiner komplexen NMDA, Serotonin und Dopamin Interaktion auch noch die Wirkung aller Opioid-Rezeptoren (Sigma, Delta, Kappa, Mu) ab. Es ist praktisch die eierlegende "Wollmilchsau" unter den Drogen und besitzt ebenfalls eine sehr hohe Affinität zum mu-Opioid Rezeptor (Agonismus), fast vergleichbar dem Morphin. "K-Holes" oder Ego-Auflösungen wird man mit diesem Mittel jedoch nicht erleben, sondern eher entspannte und gemütliche Dissoziationen ohne Manie, die einen das Leben mal aus einer anderen Perspektive betrachten lassen, ohne dabei die kognitiven Fähigkeiten negativ zu beeinflussen oder den Körper, Hirn oder die Blase zu schädigen (wie bei PCP oder Ketamin)

Ist also in seiner Wirkung deutlich vom PCP oder Ketamin zu unterscheiden. In Deutschland nach wie vor gesetzlich gesehen legal, wenn auch nur über den grauen RC-Markt zu beziehen.

[Gaucho]

Ich zitiere unter anderem zur besseren Einordnung dieser Substanz um etwaigen Missverständnissen bereits präventiv vorzubeugen - hier lediglich ein kurzer Ausschnitt von Wikipedia

"3-HO-PCP acts as a high-affinity uncompetitive antagonist of the NMDA receptor via the dizocilpine (MK-801) site (Ki = 30 nM).[3][4] It has much higher affinity than PCP for this site (Ki = 250 nM, for comparison; 8-fold difference).[4] The drug also has high affinity for the μ-opioid receptor (MOR) (Ki = 39–60 nM) in animal test subjects,[3][4][5][6] the κ-opioid receptor (KOR) (Ki = 140 nM),[5] and the sigma σ1 receptor (Ki = 42 nM; IC50 = 19 nM),[5][7][8][9] whereas it has only low affinity for the δ-opioid receptor (Ki = 2,300 nM).[5] The high affinity of 3-HO-PCP for opioid receptors is unique among arylcyclohexylamines and is in contrast to PCP, which has only very low affinity for the MOR (Ki = 11,000–26,000 nM; 282- to 433-fold difference) and the other opioid receptors (Ki = 4,100 nM for the KOR and 73,000 nM for the DOR).[4][5]

Although it was hypothesized that 3-HO-PCP might be a metabolite of PCP in humans, there is no evidence that this is the case"

[Gaucho]

Über diese Wirkungsweise von 3-HO PCP... - "3-Hydroxyphencyclidine (commonly known as 3-HO-PCP) is a novel dissociative substance of the arylcyclohexylamine class that produces potent dissociative, hallucinogenic and euphoric effects when administered. In addition to its primary activity as a NMDA receptor antagonist, it has been found to have appreciable affinity for the μ-opioid receptor."
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3-HO-PCP was first synthesized in 1978 to investigate the structure-activity relationship of phencyclidine (PCP) derivatives.It was further explored alongside PCP in the 1980s, where it was discovered to possess μ-opioid agonist activity in animal models.

Like other substances of its class, particularly methoxetamine (MXE), phencyclidine (PCP), and 3-MeO-PCE, it is known to primarily induce a state referred to as "dissociative anesthesia", albeit the extent to which this occurs has been reported to be highly dose-dependent and variable in its effects.[citation needed] It is unknown whether the studied opioid properties in animal models applies to humans, with some early reports suggesting that it does not.

Chemistry

"3-HO-PCP, or 3-hydroxyphencyclidine, is a synthetic dissociative of the arylcyclohexylamine class. The structure of 3-HO-PCP is comprised of cyclohexane, a six-member saturated ring, bonded to two additional rings at R1. One of these rings is a piperidine ring, a nitrogenous six member ring, bonded at its nitrogen group. The other ring is an aromatic phenyl ring, substituted at R3 with a hydroxy group.

3-HO-PCP is a structural analog of PCP and a homolog 3-MeO-PCP."

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Pharmacology

"Further information: NMDA receptor antagonist
Like other arylcyclohexylamine dissociatives, 3-HO-PCP acts principally as an NMDA receptor antagonist.

The NMDA (N-Methyl-D-Aspartate) receptor, a specific subtype of the glutamate receptor, modulates the transmission of electrical signals between neurons in the brain and spinal cord; for the signals to pass, the receptor must be open. Dissociatives inhibit the normal functioning NMDA receptors by binding to and blocking them. This disruption of neural network activity causes network disintegration, some research suggests, by hyperconnectivity throughout the brain. This causes an increase in noise (random, nonsensical and erraneous data) on the cerebral network and thus produces loss of normal cognitive and affective processing, psychomotor functioning, anesthesia. This is often observed in those showing psychosis or induced with high-dose IV THC or Ketamine in healthy participants, please see references.

Unlike many other dissociatives, 3-HO-PCP has also been found to have appreciable affinity as a μ-opioid receptor agonist in animal models.

However, the extent to which this applies to humans remains unknown."

[Dr.Mabuse]

Gaucho s Märchenstunde...

Es war einmal vor langer Zeit...